Article

Spatial Analysis of Malignant-Immune Cell Interactions in the Tumor Microenvironment Using Topological Data Analysis

2025-04-01

Abstract excerpt

The spatial interactions between malignant and immune cells in the tumor microenvironment (TME) play a crucial role in cancer biology and treatment response. Understanding these interactions is critical for predicting prognosis and assessing immunotherapy effectiveness. Conventional methods, which focus on local spatial features, often struggle to achieve robust analysis due to the complex and heterogeneous cellul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c4a2f89-3c00-5bc9-965b-325d93462572
DOI: 10.1101/2025.03.27.645762

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial Analysis of Malignant-Immune Cell Interactions in the Tumor Microenvironment Using Topological Data AnalysisDOI 10.1101/2025.03.27.645762Read

Multi-scale spatial modeling of immune cell distributions enables survival prediction in primary central nervous system lymphomaSemantic proximity Read

Tumor-Immune Partitioning and Clustering (TIPC) algorithm reveals distinct signatures of tumor-immune cell interactions within the tumor microenvironmentSemantic proximity Read

Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imagingSemantic proximity Read

Single-cell spatial analysis of tumor immune architecture in diffuse large B-cell lymphomaSemantic proximity Read

Prognostic significance of spatial immune profiles in human solid cancersSemantic proximity Read

Single-cell spatial analysis of tumor immune architecture in diffuse large B cell lymphomaSemantic proximity Read

The tumor microenvironment across four dimensions: assessing space and time in cancer biologySemantic proximity Read

LOCATOR: feature extraction and spatial analysis of the cancer tissue microenvironment using mass cytometry imaging technologiesSemantic proximity Read

Pan-cancer spatial characterization of key immune biomarkers in the tumor microenvironmentSemantic proximity Read

Spatial Proximity of Immune Cell Pairs to Cancer Cells in the Tumor Microenvironment as Biomarkers for Patient StratificationSemantic proximity Read

Single Cell Spatial Analysis and Biomarker Discovery in Hodgkin LymphomaSemantic proximity Read

Spatial proximity of tumor-immune interactions predicts patient outcome in hepatocellular carcinomaSemantic proximity Read