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Article

Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma

3 Apr 2020

Abstract excerpt

Despite intensive multimodal therapy, the survival rate for high risk neuroblastoma (HR-NB) remains <50%. Most cases initially respond to treatment but almost half will subsequently relapse with aggressive treatment resistant disease. Novel treatments exploiting the molecular pathology of NB and/or overcoming resistance to current genotoxic therapies are needed before survival rates can significantly improve. DNA...

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Identifiers

PMID: 32309213
DOI: 10.3389/fonc.2020.00371

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