Article

High Purity Differential Expression of Genes across Spatial Domains

2026-04-23

Abstract excerpt

Spatial transcriptomics maps gene expression within tissue architecture, offering deep insights into cellular function. A key yet overlooked phenomenon is the systematic imbalance in gene regulation within spatial domains, contrasting with traditional analyses. We define and validate this as a prevalent hallmark—High-Purity Differential Expression (HiP-DEP)—where genes in a domain shift predominantly in one direct...

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Literature Corpus work: 9c1eabca-02f9-5845-88db-fda28585c55b
DOI: 10.64898/2026.04.20.719761

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