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An explanatory benchmark of spatial domain detection reveals key drivers of method performance

2026-03-16

Abstract excerpt

The spatial organization of cells within tissues is critical for understanding biological function and disease, and spatial transcriptomics enables genome-wide mapping of this organization. Numerous computational methods aim to identify spatial domains, yet their performance is often evaluated on limited datasets, leading to conflicting conclusions. Here, we present an explanatory benchmark of 26 spatial domain de...

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Literature Corpus work
48373923-5009-5bb2-99ce-b5f471b1a311
DOI
10.64898/2026.03.12.710462
Open publication

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An explanatory benchmark of spatial domain detection reveals key drivers of method performanceDOI 10.64898/2026.03.12.710462
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