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Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes

2025-05-14

Abstract excerpt

Atypical teratoid rhabdoid tumors (ATRTs) are aggressive central nervous system tumors mainly affecting young children. Extensive molecular characterization based on gene expression and DNA methylation patterns has solidly established three major ATRT subtypes (MYC, SHH and TYR), which show distinct clinical features, setting the basis for more effective, targeted treatment regimens. Transcriptional activity of tr...

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Identifiers and source

Literature Corpus work
9c099f1c-6565-573a-9fb3-a88413f468f9
DOI
10.1101/2025.05.13.653713
Open publication

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