Article
Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.
Cell reports - 19 Nov 2019
Chun Hye-Jung E, Johann Pascal D, Milne Katy, Zapatka Marc, Buellesbach Annette, Ishaque Naveed, Iskar Murat, Erkek Serap, Wei Lisa, Tessier-Cloutier Basile, Lever Jake, Titmuss Emma, Topham James T, Bowlby Reanne, Chuah Eric, Mungall Karen L, Ma Yussanne, Mungall Andrew J, Moore Richard A, Taylor Michael D, Gerhard Daniela S, Jones Steven J M, Korshunov Andrey, Gessler Manfred, Kerl Kornelius, Hasselblatt Martin, Frühwald Michael C, Perlman Elizabeth J, Nelson Brad H, Pfister Stefan M, Marra Marco A, Kool Marcel
Abstract excerpt
Extra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss. To understand the genome-wide molecular relationships between MRTs and ATRTs, we analyze multi-omics data from 140 MRTs and 161 ATRTs. We detect similarities between the MYC subgroup of ATRTs (ATRT-MYC) and extra-cranial MRTs, including global DNA...
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