Sellar Region Atypical Teratoid/Rhabdoid Tumors (ATRT) in Adults Display DNA Methylation Profiles of the ATRT-MYC Subgroup.

doi:10.1097/PAS.0000000000001023

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Article

Sellar Region Atypical Teratoid/Rhabdoid Tumors (ATRT) in Adults Display DNA Methylation Profiles of the ATRT-MYC Subgroup.

The American journal of surgical pathology - 1 Apr 2018

Johann Pascal D, Bens Susanne, Oyen Florian, Wagener Rabea, Giannini Caterina, Perry Arie, Raisanen Jack M, Reis Gerald F, Nobusawa Sumihito, Arita Kazunori, Felsberg Jörg, Reifenberger Guido, Agaimy Abbas, Buslei Rolf, Capper David, Pfister Stefan M, Schneppenheim Reinhard, Siebert Reiner, Frühwald Michael C, Paulus Werner, Kool Marcel, Hasselblatt Martin

Abstract excerpt

Atypical teratoid/rhabdoid tumor (ATRT) is a highly malignant brain tumor predominantly encountered in infants. Mutations of the SMARCB1 gene are the characteristic genetic lesion. A small group of ATRT stands out clinically, because these tumors are located in the sellar region of adults. To investigate if sellar region ATRT in adults represents a molecular distinct entity, we characterized molecular alterations...

Topics

Adult
Age Factors
Aged
Biomarkers, Tumor
DNA Methylation
Epigenesis, Genetic
Female
Gene Deletion
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Phenotype

Pituitary Neoplasms

Point Mutation

Rhabdoid Tumor

SMARCB1 Protein

Teratoma

Source

Open in PubMed

Identifiers

PMID: 29324471
DOI: 10.1097/PAS.0000000000001023

Genes

SMARCB1
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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