Article

Circular RNA circE7 Encoded by Human Papillomavirus Facilitates Immune Evasion in Head and Neck Squamous Cell Carcinoma through Epigenetically Downregulating Galectin-9

2023-12-11

Abstract excerpt

<title>Abstract</title> <p>Immune evasion represents a crucial milestone in the progression of cancer and serves as the theoretical foundation for tumor immunotherapy. Currently, immune checkpoint inhibitors such as anti-PD-1/PD-L1 have shown promising therapeutic efficacy in clinical settings for various tumors. However, a significant proportion of tumor patients fail to benefit from this class of immune checkpo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c06ac94-ff8a-51e5-afd1-8c3986897d7e
DOI: 10.21203/rs.3.rs-3620557/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Circular RNA circE7 Encoded by Human Papillomavirus Facilitates Immune Evasion in Head and Neck Squamous Cell Carcinoma through Epigenetically Downregulating Galectin-9DOI 10.21203/rs.3.rs-3620557/v1Read

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell CarcinomaSemantic proximity Read

CircRNA Regulation of T Cells in Cancer: Unraveling Potential TargetsSemantic proximity Read

Mechanisms of immune checkpoint inhibitors: insights into the regulation of circular RNAS involved in cancer hallmarksSemantic proximity Read

SUV39H1-DNMT3A-mediated epigenetic regulation of Tim-3 and galectin-9 in the cervical cancerSemantic proximity Read

Targeting NAT10 Activates Tumor-Intrinsic Immunity and Suppresses Tumor Progression in Head and Neck Squamous Cell CarcinomaSemantic proximity Read

Tumor-educated VEGFR-3 lymphatics augment PD-1 resistance in HPV-negative HNSCCSemantic proximity Read

N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancerSemantic proximity Read

Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinomaSemantic proximity Read

Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14Semantic proximity Read

Genetic deletion of HPV E7 oncogene effectively eliminates HPV driven oropharyngeal cancer tumoursSemantic proximity Read

SUV39H1-DNMT3A-mediated epigenetic regulation of Tim-3 and galectin-9 in the cervical cancerSemantic proximity Read

Human Papillomavirus E7 Oncoprotein Subverts Host Innate Immunity via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor GenesSemantic proximity Read