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SUV39H1-DNMT3A-mediated epigenetic regulation of Tim-3 and galectin-9 in the cervical cancer

20 Jul 2020

Abstract excerpt

Abstract Background Methylation of histone 3 at lysine 9 (H3K9) and DNA methylation are epigenetic marks correlated with genes silencing. The tumor microenvironment significantly influences therapeutic responses and clinical outcomes. The epigenetic-regulation mechanism of the costimulatory factors Tim-3 and galectin-9 in cervical cancer remains unknown. Methods The methylation status of HAVCR2 and LGALS9 were...

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PMID: 32699524
DOI: 10.1186/s12935-020-01380-y

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