Article

An osmolarity dependent mechanism partially ameliorates retinal cysts and rescues cone function in a mouse model of X-linked Retinoschisis

2023-10-11

Abstract excerpt

<h4>Introduction</h4> X-linked retinoschisis (XLRS) is a vitreoretinal dystrophy caused by RS1 gene mutations which disrupt retinoschisin protein function. A vital protein for maintaining retinal architecture, the absence of functional retinoschisin leads to the development of intraretinal cysts. The preliminary goal of this study was to investigate a low dose gene therapy in Rs1 knockout ( Rs1 -KO) mice; howe...

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Literature Corpus work: 9c017814-8c25-59ae-9e25-c7717686d732
DOI: 10.1101/2023.10.09.561513

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