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Article

Role of Kir7.1 K+ channel in retinal pigment epithelium probed in a Kir7.1-M125R-expressing mutant mouse.

American journal of physiology. Cell physiology - 1 Dec 2025

Vera Erwin, Henao Juan Carlos, Cid L Pablo, Sepúlveda Francisco V, Cornejo Isabel

Abstract excerpt

Eye disease-associated K+ channel Kir7.1 is highly expressed together with the Na+-K+ pump at the apical membrane of retinal pigment epithelial cells (RPEs) that line the subretinal space (SRS). SRS K+ concentration ([K+]SRS) decreases from ∼5 to 2 mM upon light stimulation. Kir7.1 is crucial in its buffering, with failure thought to be causal in visual disease mutations of its gene. The unusual inverse relation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41247777
DOI: 10.1152/ajpcell.00690.2025

Genes

RPE
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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