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Article

Advances in understanding the molecular structure of retinoschisin while questions remain of biological function.

Progress in retinal and eye research - 1 Jul 2023

Heymann J Bernard, Vijayasarathy Camasamudram, Fariss Robert N, Sieving Paul A

Abstract excerpt

Retinoschisin (RS1) is a secreted protein that is essential for maintaining integrity of the retina. Numerous mutations in RS1 cause X-linked retinoschisis (XLRS), a progressive degeneration of the retina that leads to vision loss in young males. A key manifestation of XLRS is the formation of cavities (cysts) in the retina and separation of the layers (schisis), disrupting synaptic transmission. There are...

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Identifiers

PMID: 36402656
DOI: 10.1016/j.preteyeres.2022.101147
PMCID: PMC10185713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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