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Article

Photoreceptor deficits appear at eye opening in Rs1 mutant mouse models of X-linked retinoschisis.

Experimental eye research - 1 May 2024

Tarchick Matthew J, Beight Craig, Bonezzi Paul B, Peachey Neal S, Renna Jordan M

Abstract excerpt

X-linked retinoschisis (XLRS) is an early onset degenerative retinal disease characterized by cystic lesions in the middle layers of the retina. These structural changes are accompanied by a loss of visual acuity and decreased contrast sensitivity. XLRS is caused by mutations in the gene Rs1 which encodes the secreted protein Retinoschisin 1. Young Rs1-mutant mouse models develop key hallmarks of XLRS including...

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Source

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Identifiers

PMID: 38514024
DOI: 10.1016/j.exer.2024.109872
PMCID: PMC12817220

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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