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Article

Rs1h-/y exon 3-del rat model of X-linked retinoschisis with early onset and rapid phenotype is rescued by RS1 supplementation.

Gene therapy - 1 Aug 2022

Zeng Yong, Qian Haohua, Campos Maria Mercedes, Li Yichao, Vijayasarathy Camasamudram, Sieving Paul A

Abstract excerpt

Animal models of X-linked juvenile retinoschisis (XLRS) are valuable tools for understanding basic biochemical function of retinoschisin (RS1) protein and to investigate outcomes of preclinical efficacy and toxicity studies. In order to work with an eye larger than mouse, we generated and characterized an Rs1h-/y knockout rat model created by removing exon 3. This rat model expresses no normal RS1 protein. The...

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Identifiers

PMID: 34548657
DOI: 10.1038/s41434-021-00290-6
PMCID: PMC8938309

Genes

RS1

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