Article

Huntingtin gene CAG repeat size in patients with Lynch syndrome

2022-05-29

Abstract excerpt

Patients with Lynch syndrome (LS) are prone to cancer due to heterozygous germline pathogenic variants in genes encoding DNA mismatch repair proteins MLH1, MSH2, MSH6 and PMS2. LS cancer cells exhibit deficient DNA mismatch repair and microsatellite instability due somatic inactivation of the second copy of the affected gene. To study microsatellite characteristics in non-neoplastic cells in LS we determined CAG r...

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Literature Corpus work: 9bed68d2-53d5-506f-a98e-66ae64c9b50b
DOI: 10.1101/2022.05.28.22275723

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