Article

Genetic or pharmacological disruption of the MSH3 Y245/K246 IDL binding pocket slows CAG repeat expansion

2026-02-27

Abstract excerpt

Recent genetic studies have shown somatic expansion of the CAG repeat is the key process driving Huntington’s disease (HD) pathogenesis. Recognition of insertion deletion loops (IDLs), lesions prone to form within the CAG repeat, by Mutsβ (MSH3/MSH2) is thought to be the primary event in the expansion process. This starts a cascade that leads to error prone repair and incorporation of additional CAG units into the...

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Literature Corpus work: 566fc42d-1451-5d22-9127-2dc00db5368c
DOI: 10.64898/2026.02.26.707948

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