Article
Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes.
Neurobiology of disease - 1 Jan 2009
Dragileva Ella, Hendricks Audrey, Teed Allison, Gillis Tammy, Lopez Edith T, Friedberg Errol C, Kucherlapati Raju, Edelmann Winfried, Lunetta Kathryn L, MacDonald Marcy E, Wheeler Vanessa C
Abstract excerpt
Modifying the length of the Huntington's disease (HD) CAG repeat, the major determinant of age of disease onset, is an attractive therapeutic approach. To explore this we are investigating mechanisms of intergenerational and somatic HD CAG repeat instability. Here, we have crossed HD CAG knock-in mice onto backgrounds deficient in mismatch repair genes, Msh3 and Msh6, to discern the effects on CAG repeat size and...
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