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Article

Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer.

Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2017

Ahuja Lalima G, Kornev Alexandr P, McClendon Christopher L, Veglia Gianluigi, Taylor Susan S

Abstract excerpt

The expertise of protein kinases lies in their dynamic structure, wherein they are able to modulate cellular signaling by their phosphotransferase activity. Only a few hundreds of protein kinases regulate key processes in human cells, and protein kinases play a pivotal role in health and disease. The present study dwells on understanding the working of the protein kinase-molecular switch as an allosteric network...

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Identifiers

PMID: 28115705
DOI: 10.1073/pnas.1620667114
PMCID: PMC5307475

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