Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping the genomic landscape of MASLD: A framework for molecular subtyping and precision hepatology.

Med (New York, N.Y.) - 12 Jun 2026

Pirola Carlos José, Sookoian Silvia

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) is not merely a hepatic manifestation of systemic metabolic dysregulation, but a central node and active determinant of multi-organ derangement. As a primary cause of cirrhosis and hepatocellular carcinoma, the progression to metabolic dysfunction-associated steatohepatitis (MASH) represents a critical prognostic threshold. The pathogenesis of MASLD...

Topics

Humans
Genomics
Fatty Liver
Precision Medicine
Genetic Risk Score
Epigenesis, Genetic
Genetic Predisposition to Disease

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 42066765
DOI: 10.1016/j.medj.2026.101131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping the genomic landscape of MASLD: A framework for molecular subtyping and precision hepatology.PMID 42066765Read ↗

Unraveling Mechanisms of Genetic Risks in Metabolic Dysfunction-Associated Steatotic Liver Diseases: A Pathway to Precision Medicine.Semantic proximity Read ↗

Genomic Signatures of MASLD: How Genomics Is Redefining Our Understanding of Metabolic Liver DiseaseSemantic proximity Read ↗

Unraveling MASLD Through the Use of Omics TechnologiesSemantic proximity Read ↗

Metabolic Rewiring in MASLD: From Disease Mechanisms to Precision MedicineSemantic proximity Read ↗

Interplay between gut microbiome, host genetic and epigenetic modifications in MASLD and MASLD-related hepatocellular carcinomaSemantic proximity Read ↗

Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes.Semantic proximity Read ↗

Genetics of Metabolic Dysfunction-associated Steatotic Liver Disease: The State of the Art Update.Semantic proximity Read ↗

Role of the Gut Microbiome in Metabolic Dysfunction-Associated Steatotic Liver DiseaseSemantic proximity Read ↗

Genetic Predisposition to MASLD: Potential for Therapeutic Management.Semantic proximity Read ↗

Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism.Semantic proximity Read ↗

Genetic Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease.Semantic proximity Read ↗

Monogenic and Polygenic Risk in Common Liver Diseases: Implications for Clinical Care.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.