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Article

Heterogeneity in Colorectal Cancer: A Challenge for Personalized Medicine?

23 Nov 2018

Abstract excerpt

High inter-patient variability and high spatial heterogeneity are features of colorectal cancer (CRC). This may influence the molecular characterization of tumor tissue, now mandatory for patients with metastatic CRC who are candidates for treatment with an anti-EGFR mAb, as false-negative results can occur, leading to non optimal therapy. Moreover, temporal molecular heterogeneity during treatment is known to...

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PMID: 30477151
DOI: 10.3390/ijms19123733

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