Article

Chronic kidney disease promotes anxiety susceptibility through an angiotensin II–central amygdala axis

2026-08-20

Abstract excerpt

<h4>Background</h4> Neuropsychiatric comorbidities are highly prevalent in chronic kidney disease (CKD), yet the underlying neural mechanisms remain poorly defined. <h4>Methods</h4> We established multiple mouse models of CKD and identified an adenine-induced model as the most suitable platform to study neurobehavioral alterations. Anxiety susceptibility was operationalized as the emergence of anxiety-like behav...

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Literature Corpus work: 9b9ce6c8-7695-504c-8965-84102282eaf6
DOI: 10.64898/2026.08.16.744184

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