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Cingulate Gradient Dysfunction in End-Stage Renal Disease: Associations With Clinical Phenotypes and Exploratory Transcriptomic Signatures.

CNS neuroscience & therapeutics - 1 Jul 2026

Li Peng, Mu Jun-Ya, Zhu Xin-Yi, Yuan Hui-Jie, Luo Zhao-Yao, Zhu Qian-Ge, Niu Xuan, Feng Xiu-Long, Han Yu, Ge Ting, Wang Chen-Xi, Wang Wen, Zhang Ming

Abstract excerpt

AIMS: The cingulate cortex is highly vulnerable in end-stage renal disease (ESRD) patients, but whether ESRD disrupts its functional gradient and the links to clinical phenotypes and underlying molecular mechanisms remain unclear. METHODS: We prospectively enrolled clinical and resting-state functional MRI data from 125 participants (77 ESRD patients, 48 healthy controls) to explore cingulate gradient...

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PMID: 42381608
DOI: 10.1002/cns.70976
PMCID: PMC13320367

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