Article

USP18-STAT2 axis enhances hepatic resilience under proteotoxic stress

2026-07-13

Abstract excerpt

The liver is a metabolic hub with a high protein turnover that renders it uniquely susceptible to proteotoxic stress. Perturbation of proteostasis, either by proteasomal inhibitors or in chronic liver diseases, could adversely impact liver physiology. Here, we show that proteasomal inhibition unexpectedly suppresses basal type I interferon (IFN-I) signaling in the murine liver. Proteasomal inhibition by bortezomib...

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Literature Corpus work: 9b9a3fbd-af79-56eb-bdfa-433d73613882
DOI: 10.64898/2026.07.11.737961

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