Article

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

2022-02-02

Abstract excerpt

Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Type III IFN (IFN-λ) exhibit cell-type specific and long-lasting functions in autoinflammation, tumorigenesis and antiviral defense. Here, we identify the deubiquitinating enzyme USP22 as central regulator of basal IFN-λ secretion and SARS-CoV-2 infectio...

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Literature Corpus work: e5e85f17-03d9-594a-9602-09042290ce26
DOI: 10.1101/2022.02.01.478628

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