Article

SPIN1 promotes tumorigenesis by blocking the uL18-MDM2-p53 pathway

2017-08-18

Abstract excerpt

Ribosomal proteins (RPs) play important roles in modulating the MDM2-p53 pathway. However, less is known about the upstream regulators of the RPs. Here we identify SPIN1 (Spindlin 1) as a novel binding partner of human RPL5/uL18 that is important for this pathway. SPIN1 ablation activates p53, suppresses cell growth, reduces clonogenic ability, and induces apoptosis of cancer cells by sequestering uL18 in the nucl...

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Literature Corpus work: 25ab1329-3c05-5b49-92f6-53aa3024abe3
DOI: 10.1101/177881

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