Article

Base-edited CAR T Cells for combinational therapy against T cell malignancies

2020-07-30

Abstract excerpt

Targeting T cell malignancies using chimeric antigen receptor (CAR) T cells is hindered by ‘T v T’ fratricide against shared antigens such as CD3 and CD7. Genome-editing can overcome such hurdles through targeted disruption of problematic shared antigens. Base editing offers the possibility of seamless disruption of gene expression through the creation of stop codons or elimination of splice donor or acceptor site...

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Literature Corpus work: 9b7223ed-aca4-5cc8-a3c9-4d45116d8b8b
DOI: 10.1101/2020.07.30.228429

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