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Crocin inhibited amyloid-beta (Aβ) generation via promoting non-amyloidogenic APP processing and suppressed ER stress UPR signaling in N2a/APP cells

2021-09-16

Abstract excerpt

<h4>Background</h4> Crocin is a major active component of saffron ( Crocus sativus ) with many beneficial effects. More recently, crocin has been proposed for management of neurodegenerative diseases such as Alzheimer’s disease (AD). Here, we demonstrated for the first time that crocin reduced amyloid-beta (Aβ) generation through promoting α-cleavage of APP processing and inhibited ER stress by attenuating UPR s...

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Literature Corpus work
9b5e0498-e9e8-590a-b0bb-de9f5f63f034
DOI
10.1101/2021.09.14.460251
Open publication

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Crocin inhibited amyloid-beta (Aβ) generation via promoting non-amyloidogenic APP processing and suppressed ER stress UPR signaling in N2a/APP cellsDOI 10.1101/2021.09.14.460251
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