Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

β-Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AβPP/PS1 mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Wei Gang, Chen Yun-bo, Chen Dong-Feng, Lai Xiao-Ping, Liu Dong-Hui, Deng Ru-Dong, Zhou Jian-Hong, Zhang Sai-Xia, Li Yi-Wei, Lii Hui, Liu Liu-Fang, Wang Qi, Nie Hui

Abstract excerpt

β-Asarone, an active component of the Acori graminei rhizome that has been used as traditional Chinese herb, has been reported to be capable of inhibiting neuronal apoptosis. However, the signaling mechanism underlying the inhibitory effect of β-asarone has remained elusive. This study was aimed to investigate whether the CaMKII signaling pathway is involved in the β-asarone mediated neuroprotection. Using PC12...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Annexin A5
Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CREB-Binding Protein

Share to Fibrinolytic Agents

Share to Maze Learning

Share to Phosphopyruvate Hydratase

Share to Presenilin-1

Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 23064259
DOI: 10.3233/JAD-2012-120865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

β-Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AβPP/PS1 mice.PMID 23064259Read ↗

Crebanine, an aporphine alkaloid, induces cancer cell apoptosis through PI3K-Akt pathway in glioblastoma multiformeSemantic proximity Read ↗

Cholesterol enhances neuron susceptibility to apoptotic stimuli via cAMP/PKA/CREB-dependent up-regulation of Kv2.1.Semantic proximity Read ↗

Depichering the Effects of Astragaloside IV on AD-Like Phenotypes: A Systematic and Experimental Investigation.Semantic proximity Read ↗

Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal deathSemantic proximity Read ↗

Baicalin Attenuated A β 1-42 ‐Induced Apoptosis in SH‐SY5Y Cells by Inhibiting the Ras‐ERK Signaling PathwaySemantic proximity Read ↗

Crocin inhibited amyloid-beta (Aβ) generation via promoting non-amyloidogenic APP processing and suppressed ER stress UPR signaling in N2a/APP cellsSemantic proximity Read ↗

PI3K/Akt signaling pathway is involved in the neurotrophic effect of senegeninSemantic proximity Read ↗

An anthocyanin-rich extract from Zea mays L. var. ceratina alleviates neuronal cell death caused by hydrogen peroxide-induced cytotoxicity in SH-SY5Y cellsSemantic proximity Read ↗

Efficient strategy for alleviating neuronal apoptosis and oxidative stress damage of Alzheimer's disease through dual targeting BCL-2 gene promoter i-motif and β-amyloidSemantic proximity Read ↗

Protective effects of ginkgolide on a cellular model of Alzheimer’s disease via suppression of the NF-κB signaling pathwaySemantic proximity Read ↗

The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors.Semantic proximity Read ↗

Protective Effects of Ginkgolide on a Cellular Model of Alzheimer’s Disease via Suppression of the NF-κB Signaling PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.