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Curcumin Shows Neuroprotection against Oxidative Damage and Alters APP Processing Involving GSK-3β-mediated Protein O-GlcNAcylation

2023-05-30

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disease. Senile plaque is one of the pathological hallmarks in the AD brains, and Amyloid-β (Aβ) peptides are the main components in the senile plaque. The amyloidogenic cleavage of Amyloid-β precursor protein (APP) is a key event for Aβ product and further the formation of senile plaque. Recently, O-GlcNAcylation is suggested to regulate the pathways of APP cleavage...

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Literature Corpus work: 6cebc897-59a0-55e2-93a5-dc7ce6f795d4
DOI: 10.21203/rs.3.rs-2964826/v1

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