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Article

Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Sathya Mohan, Moorthi Ponnusamy, Premkumar Palanisamy, Kandasamy Mahesh, Jayachandran Kesavan Swaminathan, Anusuyadevi Muthuswamy

Abstract excerpt

Deterioration of cholesterol metabolism has recently been a frontier subject of investigation in the field of Alzheimer's disease (AD). Though amyloid-β protein precursor (AβPP) primes the pathological cascade, changes in cholesterol levels and its intermediates, geranyl geranyl pyrophosphate and farnesyl pyrophosphate, is expected to have a different consequence on AβPP processing and amyloid-β (Aβ) generation....

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Identifiers

PMID: 28059793
DOI: 10.3233/JAD-161034

Genes

ADAM10
BACE1
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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