Back to search

Article

Decoding Humoral Immunity During Acute MPXV Infection via Comprehensive Serological Analysis and Antigen-agnostic Monoclonal Antibody Profiling

2026-08-31

Abstract excerpt

Dissecting the complexity of antibody responses in orthopoxvirus (OPXV) infected individuals is essential for elucidating protective mechanisms and identifying candidate protective immunogens. Here, we profiled the acute humoral response in 51 mpox cases, showing distinct IgG trajectories among multiple antigens alongside the rise of plasma neutralizing activities to plateau within 6 weeks after symptom onset. Uti...

Identifiers and source

Literature Corpus work
9b48354e-08ce-5c10-9c4e-6446bdd7d5ec
DOI
10.64898/2026.08.21.26360138
Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Decoding Humoral Immunity During Acute MPXV Infection via Comprehensive Serological Analysis and Antigen-agnostic Monoclonal Antibody ProfilingDOI 10.64898/2026.08.21.26360138
Identification of neutralizing antibodies against monkeypox virus using high-throughput sequencing of A35+H3L+B cells from patients with convalescent monkeypoxSemantic proximity
Mpox vaccine and infection-driven human immune signaturesSemantic proximity
The unique immune evasion mechanisms of the mpox virus and their implication for developing new vaccines and immunotherapiesSemantic proximity
Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1Semantic proximity
A Review of the Molecular Understanding of the Mpox Virus (MPXV): Genomics, Immune Evasion, and Therapeutic TargetsSemantic proximity
Two noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infectionsSemantic proximity
Single-cell sequencing reveals clonally expanded plasma cells during chronic viral infection produce virus-specific and cross-reactive antibodiesSemantic proximity
Systematic analysis of human antibody response to ebolavirus glycoprotein reveals high prevalence of neutralizing public clonotypesSemantic proximity
Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining.Semantic proximity
Mpox in the Post-2022 Era: A Comprehensive Review of Viral Evolution, Host Adaptation, and Clinical ManagementSemantic proximity
Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccinesSemantic proximity
Comprehensive Profiling of Monkeypox Virus Antigens Identifies Potent Targets for Next-Generation mRNA Vaccine DevelopmentSemantic proximity
Select a neighboring publication to make it the new centre.