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Two noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infections

31 May 2024

Abstract excerpt

The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level to the MPXV B6 protein in vaccinia vaccinees born before the end of the immunization program and then identified two monoclonal antibodies (MAbs), hMB621 and hMB668, targeting distinct epitopes on B6, from one vaccinee. Binding assays...

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PMID: 38821921
DOI: 10.1038/s41467-024-48312-2

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