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Article

Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization

7 Feb 2023

Abstract excerpt

Endogenous retroviruses (ERVs) have been proposed as a driving force for the evolution of the mammalian placenta, however, the contribution of ERVs to placental development and the underlying regulatory mechanism remain largely elusive. A key process of placental development is the formation of multinucleated syncytiotrophoblasts (STBs) in direct contact with maternal blood, through which constitutes the...

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PMID: 36864754
DOI: 10.1093/nar/gkad109

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