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Article

A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2005

Hanover John A, Forsythe Michele E, Hennessey Patrick T, Brodigan Thomas M, Love Dona C, Ashwell Gilbert, Krause Michael

Abstract excerpt

O-linked N-acetylglucosamine (O-GlcNAc) is an evolutionarily conserved modification of nuclear pore proteins, signaling kinases, and transcription factors. The O-GlcNAc transferase (OGT) catalyzing O-GlcNAc addition is essential in mammals and mediates the last step in a nutrient-sensing "hexosamine-signaling pathway." This pathway may be deregulated in diabetes and neurodegenerative disease. To examine the...

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Identifiers

PMID: 16051707
DOI: 10.1073/pnas.0408771102
PMCID: PMC1183534

Genes

OGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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