Article

Polygenic risk of cardiovascular disease manifests in cardiac structure and function

2026-06-08

Abstract excerpt

Cardiovascular diseases (CVDs) are highly heritable, but pathogenesis at the organ and physiological level is still poorly defined. Polygenic risk scores (PRSs), which estimate individual genetic susceptibility to a disease, may allow for the identification of associated abnormal organ structures. Ultimately, identifying where cardiovascular polygenic risk manifests can guide early interventions, shape mechanistic...

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Literature Corpus work: 9af74cc3-f64e-58b0-8850-ebb8ff069952
DOI: 10.64898/2026.06.07.26354998

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