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Article

Monogenic and Polygenic Contributions to Cardiomyopathy and Heart Failure Across Diverse Populations

2026-05-08

Abstract excerpt

<title>Abstract</title> <p>Pathogenic variants in cardiomyopathy genes confer substantial disease risk, yet clinical penetrance varies widely. The population-level prevalence, age-specific penetrance, and the extent to which polygenic susceptibility modifies disease risk across diverse ancestries remain poorly defined. This population-based cohort study leveraged genome sequencing and linked electronic health rec...

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Literature Corpus work
fbc6280a-bd81-5984-8793-d950c035c31d
DOI
10.21203/rs.3.rs-9581360/v1
Open publication

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Monogenic and Polygenic Contributions to Cardiomyopathy and Heart Failure Across Diverse PopulationsDOI 10.21203/rs.3.rs-9581360/v1
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