Article
Cardiomyopathy Gene Variants and Polygenic Risk Scores in Atrial Fibrillation: Evidence for an Atrial-First Phenotype.
Journal of the American College of Cardiology - 17 Mar 2026
da Rocha Guilherme L, Feiner James, Lazarte Julieta, Pang Keona, Li Yanran, Le Ann, Man Alice, Pathan Nazia, Whitlock Richard P, Belley-Côté Emilie P, Conen David, Wong Jorge A, McIntyre William F, Healey Jeff S, Bezzina Connie R, Watkins Hugh, Ware James S, Tadros Rafik, Paré Guillaume, Roberts Jason D
Abstract excerpt
BACKGROUND: Atrial fibrillation (AF) is heritable and its complex underlying genetic substrate is gradually being unraveled. OBJECTIVES: We sought to explore the impact of disease-causing cardiomyopathy variants on the risk of AF after adjustment for incident ventricular cardiomyopathy and clinical heart failure in 2 cohort studies (UK Biobank [UKB] and All of Us [AoU]) and evaluate the utility of polygenic risk...
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