Article

TDP-43 subtypes shape transcriptomic signatures in Alzheimer’s disease

2026-06-26

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) pathology frequently co-occurs with Tau neurofibrillary tangles (NFTs) and amyloid β plaques in Alzheimer’s disease (AD), driving significant clinical heterogeneity. Whether TDP-43 engages autonomous molecular programs or instead amplifies Tau-driven neurodegeneration remains difficult to resolve, largely because these pathologies often co-occur. To separate these overlapping si...

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Literature Corpus work: 1aa1905d-cc37-5726-b316-d9503fb62930
DOI: 10.64898/2026.06.22.733827

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