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Article

GBA1 Gene Mutations in α-Synucleinopathies-Molecular Mechanisms Underlying Pathology and Their Clinical Significance.

International journal of molecular sciences - 20 Jan 2023

Granek Zuzanna, Barczuk Julia, Siwecka Natalia, Rozpędek-Kamińska Wioletta, Kucharska Ewa, Majsterek Ireneusz

Abstract excerpt

α-Synucleinopathies comprise a group of neurodegenerative diseases characterized by altered accumulation of a protein called α-synuclein inside neurons and glial cells. This aggregation leads to the formation of intraneuronal inclusions, Lewy bodies, that constitute the hallmark of α-synuclein pathology. The most prevalent α-synucleinopathies are Parkinson's disease (PD), dementia with Lewy bodies (DLB), and...

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Identifiers

PMID: 36768367
DOI: 10.3390/ijms24032044
PMCID: PMC9917178

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