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Nuclear PHGDH promotes neutrophil recruitment to drive liver cancer progression

2021-10-18

Abstract excerpt

Metabolic dysregulation and the communications between cancer and immune cells are emerging as two essential features of malignant tumors. In this study, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) associates with poor prognosis of liver cancer patients, and Phgdh is required for liver cancer progression in a mouse model. Unexpectedly, the impairment of Phgdh enzyme activity exe...

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Identifiers and source

Literature Corpus work
017331bf-8ea3-55e7-9450-9c455dedb5a1
DOI
10.1101/2021.10.17.464745
Open publication

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Nuclear PHGDH promotes neutrophil recruitment to drive liver cancer progressionDOI 10.1101/2021.10.17.464745
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