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Article

Plk1 regulates mutant IDH1 enzyme activity and mutant IDH2 ubiquitination in mitosis.

Cellular signalling - 1 Apr 2022

Saikiran Reddy M, Bhattacharjee Debanjan, Jain Nishant

Abstract excerpt

Mutations in the metabolic enzymes, IDH1 and IDH2 are frequently found in glioma, chondrosarcoma, and acute myeloid leukemia. In our previous study, we showed that mutant IDH1 and IDH2 proteins levels are high in mitosis, and mutant IDH1 enzyme activity increases in mitosis. In another study, we observed that mutant IDH2 is ubiquitinated in mitosis in an APC/C-dependent manner. To orchestrate mitosis, kinases...

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PMID: 35143931
DOI: 10.1016/j.cellsig.2022.110279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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