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Article

Prohibitin2 knockdown decreases glioma malignant phenotypes and radio-resistance by inhibiting mitophagy.

International journal of radiation biology - 1 Jan 2025

Xue Xuefei, Tan Huiling, Jiang Xingning, Lu Jingfan, Sun Ting, Yang Wei

Abstract excerpt

PURPOSE: Prohibitin2 (PHB2), located in inner mitochondrial membrane (IMM), is an important receptor to induce mitophagy. PHB2 was identified as a cancer-promoting factor in most cancers. However, the function of PHB2 in glioma cells remains unclear. This study delved into the impact of PHB2 knockdown on the phenotype, radiosensitivity and mitophagy of glioma cells. METHODS: PHB2 expression and its clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40029335
DOI: 10.1080/09553002.2025.2470203

Genes

PHB2
PARL
PGAM5
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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