Article

Genotoxicity Assessment of Hwanglyeonhaedok-Tang: An Herbal Formula Evaluated Using the In Vivo Alkaline Comet Assay and Pig-a Gene Mutation Assay in Rats

2025-08-08

Abstract excerpt

<title>Abstract</title> <p>Background Hwanglyeonhaedok-tang (HHT), also known as Huang-lian-jie-du-tang or Oren-gedoku-to, is a popular herbal formula in traditional Asian medicine. Despite the clinical effectiveness of herbal formulas, concerns regarding the quality, safety, and efficacy persist. HHT exhibited genotoxicity in bacterial reverse mutation (Ames test) and <italic>in vitro</italic> chromosomal aberra...

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Literature Corpus work: 9aaf2fc8-7759-5a31-a363-3da2ab1c2e4d
DOI: 10.21203/rs.3.rs-6303752/v1

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