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In vivo alkaline comet assay: Statistical considerations on historical negative and positive control data.

Regulatory toxicology and pharmacology : RTP - 1 Mar 2024

Tug Timur, Duda Julia C, Menssen Max, Bruce Shannon Wilson, Bringezu Frank, Dammann Martina, Frötschl Roland, Harm Volker, Ickstadt Katja, Igl Bernd-Wolfgang, Jarzombek Marco, Kellner Rupert, Lott Jasmin, Pfuhler Stefan, Plappert-Helbig Ulla, Rahnenführer Jörg, Schulz Markus, Vaas Lea, Vasquez Marie, Ziegler Verena, Ziemann Christina

Abstract excerpt

The alkaline comet assay is frequently used as in vivo follow-up test within different regulatory environments to characterize the DNA-damaging potential of different test items. The corresponding OECD Test guideline 489 highlights the importance of statistical analyses and historical control data (HCD) but does not provide detailed procedures. Therefore, the working group "Statistics" of the German-speaking...

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PMID: 38401761
DOI: 10.1016/j.yrtph.2024.105583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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