Article
Genotoxicity assessment of Hwanglyeonhaedok-tang: an herbal formula evaluated using the in vivo alkaline comet assay and Pig-a gene mutation assay in rats.
BMC complementary medicine and therapies - 17 Apr 2026
Back Seng-Min, Gu Eun-Young, Han Kang-Hyun, Seo Chang-Seob, Jang Min Seong, Jeung Na-Young, Kim Nan-Young, Kim Da Yeon, Jung Soyoung, Kim Yong-Bum, Park Seong-Hoon
Abstract excerpt
BACKGROUND: Hwanglyeonhaedok-tang (HHT), also known as Huang-lian-jie-du-tang or Oren-gedoku-to, is a popular herbal formula in traditional Asian medicine. Despite the clinical effectiveness of herbal formulas, concerns regarding the quality, safety, and efficacy persist. HHT exhibited genotoxicity in bacterial reverse mutation (Ames test) and in vitro chromosomal aberration (CA) test, warranting further...
Topics
- Animals
- Rats
- Comet Assay
- Male
- Drugs, Chinese Herbal
- Mutagenicity Tests
- Rats, Sprague-Dawley
- Membrane Proteins
- DNA Damage
- Mutation