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Clinicopathological and genomic features of early-onset non-small cell lung cancer across age and ethnicity.

International journal of cancer - 15 Jul 2026

Huang Pingzhi, Song Jialin, Liu Jun, Li Yujun, Xie Jianjiang, Li Baoxiu, Yang Jing, Hou Jun, Zhao Zhuxiang

Abstract excerpt

Lung cancer in young patients shows a rising incidence and distinct disease biology but remains understudied. We obtained clinical information and somatic mutation data for two large non-small-cell lung cancer (NSCLC) patient cohorts from the cBioPortal database-the China cohort (N = 1948) and the MSK cohort (N = 6220). Additionally, we extracted clinical data from an internal, real-world NSCLC patients (GZSY...

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Identifiers

PMID: 41793321
DOI: 10.1002/ijc.70425

Genes

EGFR
ERBB2
TP53
ALK
ROS1

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