Article
Integrated Genomic and Immune Profiling of Early Onset Lung Cancer in East Asians Reveals a Distinct Molecular Architecture.
Clinical lung cancer - 1 Sept 2026
Wang Jianhua, Lu Zhongyu, Ge Minghui, Zhang Xing, Chen Dongsheng, Peng Xiaohong
Abstract excerpt
BACKGROUND: The age cut-off for early-onset lung cancer (EOLC) varies across studies (40-50 years). Here, we define EOLC as diagnosis at ≤ 40 years, a threshold identifying a subgroup with distinct clinical characteristics. However, whether EOLC differs fundamentally from late-onset lung cancer (LOLC) at the molecular level and represents a distinct subtype requiring different management remains unclear. METHODS:...
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- Humans
- Female
- Lung Neoplasms
- Biomarkers, Tumor
- Genomics
- Male
- Age of Onset