Article

Targeting stress-induced senescent cells prolongs corneal allograft survival

2023-01-17

Abstract excerpt

<h4>Background: </h4> and Purpose: Allograft rejection and corneal endothelial dysfunction are the two leading causes of corneal transplantation failure, but the underlying pathogenesis remains largely uncertain. Experimental Approaches: Using murine orthotopic corneal transplantation model, we analyzed the cellular senescence of allografts at early stage after transplantation through senescence-associated β-galac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9a6eabad-9bcb-5698-a78f-df9169ea058a
DOI: 10.22541/au.167394655.54118304/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting stress-induced senescent cells prolongs corneal allograft survivalDOI 10.22541/au.167394655.54118304/v1Read

Cellular Senescence Exacerbates Features of Aging in the EyesSemantic proximity Read

New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular DiseasesSemantic proximity Read

Senescence‐associated secretory phenotype promotes chronic ocular graft‐vs‐host disease in mice and humansSemantic proximity Read

TGF-β and NF-κB signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress responseSemantic proximity Read

Phenotypic and functional characterization of corneal endothelial cells during in vitro expansionSemantic proximity Read

Cellular senescence and glaucomaSemantic proximity Read

Phenotypic and functional characterization of corneal endothelial cells during in vitro expansion.Semantic proximity Read

Retinoblastoma ( Rb ) promotes senescence of corneal endothelial cells by inhibiting the activation of E2F2Semantic proximity Read

PD ‐ L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC ‐ RPE Grafts in Retinal DegenerationSemantic proximity Read

The Senescence Difference Between the Central and Peripheral Cornea Induced by SuturesSemantic proximity Read

Aging, Cellular Senescence, and GlaucomaSemantic proximity Read

Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cellsSemantic proximity Read