Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells

16 Nov 2018

Abstract excerpt

. However, age-related MSC changes involve loss of function and acquisition of a senescence-associated secretory phenotype (SASP), which can contribute to the maintenance of a chronic state of low-grade inflammation in tissues and organs.In a previous study we isolated, characterized, and differentiated RPESCs. Here, we induced replicative senescence in RPESCs and tested their acquisition of the senescence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal Surgery and Treatments
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30444724
DOI: 10.18632/aging.101624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cellsPMID 30444724Read ↗

Cellular Senescence Exacerbates Features of Aging in the EyesSemantic proximity Read ↗

New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular DiseasesSemantic proximity Read ↗

The Emerging Role of Senescence in Ocular Disease.Semantic proximity Read ↗

Reversed Senescence of Retinal Pigment Epithelial Cell by Coculture With Embryonic Stem Cell via the TGFβ and PI3K PathwaysSemantic proximity Read ↗

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.Semantic proximity Read ↗

Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular DegenerationSemantic proximity Read ↗

Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune HomeostasisSemantic proximity Read ↗

Senescence targeting re-enables injury-responsive repair in a human RPE aging modelSemantic proximity Read ↗

Airway Epithelium Senescence as a Driving Mechanism in COPD PathogenesisSemantic proximity Read ↗

Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE–ChoroidSemantic proximity Read ↗

Accelerated aging phenotypes in the retinal pigment epithelium of Zmpste24-deficient mice.Semantic proximity Read ↗

Retinoblastoma ( Rb ) promotes senescence of corneal endothelial cells by inhibiting the activation of E2F2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.