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Article

The Long and the Short of PTEN in the Regulation of Mitophagy

13 May 2020

Abstract excerpt

Mitophagy is a key mitochondrial quality control mechanism for effective and selective elimination of damaged mitochondria through the autophagy-lysosome machinery. Defective mitophagy is associated with pathogenesis of important human diseases including neurodegenerative diseases, heart failure, innate immunity, and cancer. In the past two decades, the mechanistic studies of mitophagy have made many...

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PMID: 32478067
DOI: 10.3389/fcell.2020.00299

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